Research Results
The most fascinating bioactivity of Clarinol™ is its effect on the body’s fat to muscle ratio. The following paragraphs describe briefly the studies demonstrating the effects on growth and body composition.
Animal studies
The body fat reducing effect of CLA has been observed in many animal studies using rats, mice, hamsters, pigs and chickens. Such an effect was not limited to young animals but was also noticed in adults (Chin et al., 1994, Pariza et al., 1996, Albright et al., 1996, Park et al., 1997, Ostrowska et al.,1999, West et al., 1998, Delany et al., 1999, de Deckere et al., 1999).
Human Trials
A number of human clinical trials have produced a growing body of evidence pointing at the effectiveness of CLA in the control and management of body weight.
- A small clinical trial of 20 non-obese people showed a 20% reduction in body fat. A subsequent larger scale trial with 80 obese people lasting 6 months demonstrated that those treated with CLA did not regain fat mass to the same extent as those not taking CLA. This suggests that CLA preferentially produces deposition of muscle mass rather than fat mass (Atkinson et al., 1999).
In another study 60 overweight or obese volunteers were treated with CLA for 12 weeks. In this study a dose over 3.4g of CLA per day caused a significant reduction in body fat mass (Blankson et al., 2000). Safety parameters analyzed during this study revealed no adverse effects resulting from CLA treatment (Berven et al., 2000).
A Medstat research study fed 1.8 grams of CLA per day for 12 weeks to 20 healthy volunteers. A significant reduction in body fat (20%) was obtained during the study for the CLA group, while no effect was seen in the group not taking CLA (Thom et al., 1997).
CLA supplementation had no effect on the parameters examined and no adverse effects were observed in a study examining the effect of CLA (different forms) supplementation (3g/d) for 64 days on body composition, immune parameters and related events in 17 adult healthy women. (Zambell et al. 2000, Medina et al., 2000, Kelley et al., 2000). The CLA used in this study contained several isomers of CLA, the two active isomers, c9-t11 CLA and t10-c12 CLA, were diluted to a greater extent than in the previous studies. This may account for the lack of effect in this study.
A trial using 24 novice body builders consuming a daily dose of 7.2g of CLA or a placebo for 6 weeks while completing body building exercises (Lowery et al., 1998) was used to investigate the effect of CLA on muscle development. An increase in skin-fold-corrected arm girth, body mass and leg press was seen in the CLA group compared with the placebo. A similar trial investigated 28 days of CLA supplementation (6g/d) in 24 experienced resistance-trained males (Ferreira et al., 1997). Analysis showed that those athletes taking CLA improved their bench press and leg press strength considerably compared with the athletes taking placebos.
These studies clearly show the positive effects CLA has on the fat to muscle ratio and the resulting body profile improvement. A well known shortcoming of weight loss diets is the yo-yo effect where the dieters gains most if not all of the weight back in a short time after the diet stops. CLA has been observed to dampen this yo-yo effect considerably.
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